#2865 EARLY REPEAT HOSPITALIZATION FOR FLUID OVERLOAD IN INDIVIDUALS WITH CARDIOVASCULAR RISKS

Abstract Background and Aims Fluid overload is a common manifestation of cardiovascular kidney disease leading cause for hospitalizations. To identify patients at-risk recurrent severe fluid who can benefit from strategies to reduce hospitalizations, we evaluated the incidence risk factors associated with early repeat hospitalization among individuals risks. Method Single-center retrospective cohort study consecutive adults an index between January 2015 December 2017 had risks (older age, diabetes mellitus, hypertension, dyslipidemia, disease) and/or disease, but excluded if lost follow up or eGFR <15 ml/min/1.73 m2. Comorbidities, biochemistry medications were retrieved electronic medical records. The primary outcome was within 30 days discharge. Binary logistic regression (enter method) used assess hospitalizations in literature p≤0.25 on univariate analysis. Discrimination calibration model assessed by area (AUC) under receiver operating characteristic (ROC) curve Hosmer-Lemeshow goodness-of-fit test, respectively. Results Among 3423 unique overload, mean age 73.9 ± 11.6 years 16.7% required high-dose intravenous (IV) furosemide. median length stay (LOS) 4 (2, 9) 95.3% prescribed loop diuretics at Early occurred 291 (8.5%). After adjusting demographic (age, gender, ethnicity), comorbidities (recent hospitalization, atrial fibrillation, diabetes), before (diuretic, RAS blocker, NSAID), clinical parameters during (systolic BP, eGFR, IV furosemide use, LOS) discharge statin), (adjusted OR 1.66, 95% CI 1.26-2.17, p<0.001), prior 3 months 2.52, 1.17-5.44, p = 0.02), any 6 1.33, 1.02-1.73, 0.04) 1.58, 1.10-2.28, 0.01) increased overload. Higher systolic BP admission 0.992, 0.986-0.998, diuretic 0.50, 0.26-0.98, reduced accuracy 91.5% Hosmer Lemmeshow Test chi-square 0.25. AUC ROC 0.639 (95% 0.606 – 0.671). Conclusion Patients lower need lack